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Hisashi Yamanaka Selected Research

Antirheumatic Agents (DMARD)

5/2024Factors contributing to the improvement in J-HAQ after 3 years of treatment with abatacept in biologic-naïve rheumatoid arthritis patients: Interim results of a long-term, observational, multicentre study in Japan (ORIGAMI).
1/2024MHC-DRB alleles with amino acids Val11, Phe13, and the shared epitopes promote collagen-induced arthritis and a rapid IgG1 response in Filipino cynomolgus macaques.
9/2023Factors associated with sarcopenia in Japanese patients with rheumatoid arthritis: results from the IORRA cohort study.
7/2023Evaluation of RABBIT risk score in Japanese patients with rheumatoid arthritis starting first bDMARDs: a validation study using the IORRA cohort data.
1/2023Long-term Evaluation of E6011, an Anti-Fractalkine Monoclonal Antibody, in Patients with Rheumatoid Arthritis Inadequately Responding to Biological Disease-modifying Antirheumatic Drugs.
1/2023Socioeconomic impact of treatment with biological disease-modifying antirheumatic drugs in Japanese patients with rheumatoid arthritis.
8/2022Effectiveness and safety of subcutaneous abatacept in biologic-naïve RA patients at Week 52: A Japanese multicentre investigational study (ORIGAMI study).
7/2022Differences in patients' population and efficacy/effectiveness of biologic disease-modifying antirheumatic drugs between randomized controlled trials and real-world settings in patients with rheumatoid arthritis - using the IORRA cohort.
2/2022Systematic review for the treatment of older rheumatoid arthritis patients informing the 2020 update of the Japan College of Rheumatology clinical practice guidelines for the management of rheumatoid arthritis.
1/2022Systematic review and meta-analysis of biosimilar for the treatment of rheumatoid arthritis informing the 2020 update of the Japan College of Rheumatology clinical practice guidelines for the management of rheumatoid arthritis.
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Hisashi Yamanaka Research Topics

Disease

207Rheumatoid Arthritis
05/2024 - 04/2002
21Gout
12/2021 - 08/2005
20Infections
10/2023 - 01/2005
15Hyperuricemia
12/2021 - 01/2003
15Systemic Lupus Erythematosus (Libman-Sacks Disease)
01/2017 - 11/2003
14Pain (Aches)
09/2023 - 12/2005
14Interstitial Lung Diseases (Interstitial Lung Disease)
07/2019 - 07/2010
14Dermatomyositis (Dermatopolymyositis)
07/2019 - 07/2010
7Drug-Related Side Effects and Adverse Reactions
10/2023 - 12/2002
7Arthritis (Polyarthritis)
01/2018 - 01/2010
6Systemic Scleroderma (Systemic Sclerosis)
01/2019 - 05/2011
5Neoplasms (Cancer)
07/2023 - 09/2012
5Herpes Zoster
04/2022 - 10/2014
5Gouty Arthritis
01/2021 - 09/2002
5Osteoporosis
01/2021 - 01/2009
5Melanoma (Melanoma, Malignant)
01/2018 - 09/2012
5Myositis (Idiopathic Inflammatory Myopathies)
01/2018 - 07/2012
5Autoimmune Diseases (Autoimmune Disease)
08/2017 - 07/2008
5Inflammation (Inflammations)
08/2017 - 01/2007
4Lupus Nephritis
01/2020 - 08/2011
4Fibrosis (Cirrhosis)
01/2019 - 09/2010
4Polymyositis
01/2018 - 10/2010
4Rheumatic Diseases (Rheumatism)
11/2017 - 01/2007
3Hypertension (High Blood Pressure)
10/2023 - 11/2010
3Psoriasis (Pustulosis Palmaris et Plantaris)
10/2023 - 08/2012
3Hypersensitivity (Allergy)
10/2023 - 01/2006
3Vitamin D Deficiency
01/2021 - 07/2013
3Psoriatic Arthritis
06/2019 - 10/2012
3Genetic Predisposition to Disease (Genetic Predisposition)
01/2019 - 01/2015
3Synovitis
01/2018 - 01/2009
3Pneumonia (Pneumonitis)
10/2011 - 06/2010
2Crohn Disease (Crohn's Disease)
10/2023 - 01/2014
2Injection Site Reaction
01/2023 - 07/2015

Drug/Important Bio-Agent (IBA)

48Methotrexate (Mexate)FDA LinkGeneric
07/2023 - 04/2002
34Antirheumatic Agents (DMARD)IBA
05/2024 - 12/2002
24Uric Acid (Urate)IBA
10/2023 - 09/2002
19Adalimumab (Humira)FDA Link
05/2020 - 04/2011
17Adrenal Cortex Hormones (Corticosteroids)IBA
09/2023 - 01/2007
16tocilizumab (atlizumab)FDA Link
05/2020 - 04/2011
15Monoclonal AntibodiesIBA
01/2023 - 01/2008
15Etanercept (Enbrel)FDA Link
01/2023 - 01/2006
13Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA
07/2021 - 01/2006
12ametantrone (HAQ)IBA
05/2024 - 12/2005
12Proteins (Proteins, Gene)FDA Link
11/2019 - 03/2007
11Infliximab (Remicade)FDA Link
10/2023 - 01/2007
10Abatacept (Orencia)FDA Link
05/2024 - 09/2014
10AntibodiesIBA
01/2018 - 06/2011
9Certolizumab PegolFDA Link
03/2020 - 07/2014
9AutoantibodiesIBA
01/2018 - 06/2011
9CytokinesIBA
08/2017 - 07/2008
8FebuxostatFDA Link
12/2021 - 06/2011
8HLA-DRB1 Chains (HLA DRB1)IBA
01/2018 - 12/2011
7EpitopesIBA
01/2024 - 01/2012
7DenosumabFDA Link
11/2021 - 06/2016
7Tacrolimus (Prograf)FDA LinkGeneric
01/2021 - 10/2010
7Prednisolone (Predate)FDA LinkGeneric
05/2020 - 06/2011
7Rheumatoid FactorIBA
11/2019 - 01/2007
6Peptides (Polypeptides)IBA
05/2023 - 01/2013
6Tumor Necrosis Factor InhibitorsIBA
02/2023 - 04/2012
6golimumabFDA Link
09/2018 - 06/2012
6Interleukin-6 (Interleukin 6)IBA
01/2018 - 10/2009
6Ferritins (Ferritin)IBA
01/2018 - 07/2010
5Amino AcidsFDA Link
01/2024 - 10/2013
5Biosimilar PharmaceuticalsIBA
10/2023 - 03/2020
5SteroidsIBA
10/2023 - 05/2007
5Non-Steroidal Anti-Inflammatory Agents (NSAIDs)IBA
09/2023 - 01/2005
5C-Reactive ProteinIBA
08/2023 - 01/2007
5Allopurinol (Remid)FDA LinkGeneric
12/2021 - 06/2011
5Anti-Citrullinated Protein AntibodiesIBA
03/2020 - 05/2011
5bucillamine (SA 96)IBA
01/2020 - 01/2005
5Sulfasalazine (Azulfidine)FDA LinkGeneric
01/2020 - 12/2002
5tofacitinibIBA
09/2019 - 10/2014
5Biomarkers (Surrogate Marker)IBA
07/2019 - 01/2009
5EnzymesIBA
11/2018 - 12/2002
5Interleukin-17 (Interleukin 17)IBA
08/2017 - 10/2009
5DNA (Deoxyribonucleic Acid)IBA
03/2014 - 01/2009
5purineIBA
06/2011 - 03/2011
5Xanthine OxidaseIBA
06/2011 - 06/2011
4CT-P13IBA
10/2023 - 01/2015
4cyclic citrullinated peptideIBA
05/2023 - 05/2011
4Chemokine CX3CL1IBA
01/2023 - 01/2021
4quetmolimabIBA
01/2023 - 01/2021
4Interleukin-18 (Interleukin 18)IBA
04/2014 - 10/2010
4Therapeutic UsesIBA
08/2012 - 01/2005
3Immunoglobulin G (IgG)IBA
01/2024 - 05/2011
3InterleukinsIBA
07/2021 - 01/2016
3hydroxide ionIBA
01/2021 - 07/2013
3Leflunomide (Arava)FDA LinkGeneric
01/2020 - 06/2003
3Cyclophosphamide (Cytoxan)FDA LinkGeneric
01/2020 - 06/2011
3sirukumabIBA
03/2019 - 01/2018
3HLA Antigens (Human Leukocyte Antigens)IBA
10/2018 - 01/2014
3Amino Acyl-tRNA Synthetases (Aminoacyl-tRNA Synthetase)IBA
12/2014 - 09/2012
3Nucleic AcidsIBA
07/2012 - 04/2008
3Matrix Metalloproteinases (MMPs)IBA
01/2010 - 01/2005
2CollagenIBA
01/2024 - 05/2013
2omega-Chloroacetophenone (Mace)IBA
02/2023 - 10/2016
2olokizumabIBA
07/2021 - 01/2016

Therapy/Procedure

43Therapeutics
01/2022 - 06/2004
3Biological Therapy
07/2023 - 01/2009
3Knee Replacement Arthroplasty (Total Knee Replacement)
10/2010 - 01/2007